The mission of BDSP is to facilitate brain health research by offering free access to large collections of neurophysiological, brain imaging, genetics, omics, and associated clinical data and open-source software. BDSP will also host periodic competitions, inviting the research community to solve open problems in neurology related to diagnosis, prognostication, and medical decision making. Members of BDSP are actively developing new ways to analyze neurophysiologic signals, particularly electroencephalography (EEG) and polysomnography (PSG) signals, and to relate these to important clinical outcomes.
BDSP is managed by members of the McCance Center for Brain Health at Massachusetts General Hospital (MGH), and the Clinical Data Animation Center (CDAC) at Beth Israel Deaconess Medical Center, which are affiliate hospitals of Harvard Medical School.
The BDSP has five main components:
- Data: An extensive collection of recordings of physiologic signals and related clinical data for use by the biomedical research community. BDSP includes collections of neurophysiology and other related biomedical signals from healthy subjects and patients with a wide variety of neurologic and medical conditions, including epilepsy, seizures and status epilepticus, anoxic brain injury and coma following cardiac arrest, sleep apnea, insomnia, delirium, neurodenerative diseases including Alzheimer's disease and related dementias, neurotoxicity related to cancer treatments, ischemia and hemorrhagic stroke, among many other conditions. These data collections include data from a wide range of research studies conducted and contributed by members of the research community. As BDSP grows it will also include imaging data, genetics, and clinical trials data.
- Code: A library of broadly applicable computer programs for neurophysiologic signal processing and analysis, detection of clinically significant events, interactively viewing and annotating signals. Examples include software for detecting interictal epileptiform discharges; harmful brain activity including seizures and periodic and rhythmic patterns; sleep disturbances like obstructive and central apneas and periorid limb movements during sleep; and interactive EEG and PSG viewers for visual analysis and labeling of data.
- Publications: A collection of code and data for reproducing the results (figures and tables) of published research studies, to support reproducible research.
- Education: Tools for clinical trainees and practicing clinicians who interpret EEGs and PSGs, to measure performance at key tasks (e.g. recognizing epileptiform discharges, scoring sleep stages), to provide practice, and to help reduce noise and bias and increase reliability of the medical community in reaching diagnoses that rely on interpretation of clinical neurophysiology data.
- Computing: A cloud-based computing platform for conducting research on the data. This is provided in collaboration with NHLBI [Biodata Catalyst](https://biodatacatalyst.nhlbi.nih.gov/)
All data and code included in BDSP are carefully reviewed. We invite members of the research community to participate in the review process. By sharing data sets and software freely, the research community benefits from access to materials that have been rigorously reviewed by many investigators. We invite researchers to contribute data and software for review and inclusion on the platform. Guidelines for contributors can be found can be found here.
Major contributors and close collaborators of the BDSP include
- Beth Israel Deaconess Medical Center: Robert J. Thomas, MD, Haoqi Sun, PhD, Jin Jing, PhD, Daniel Goldenholz, MD, PhD, Mouhsin Shafi, MD, PhD, M. Brandon Westover, MD, PhD
- Massachusetts General Hospital: Valdery Moura Junior, MSc, MBA, Sahar Zafar MD, Alice Lam, MD, PhD, Shibani Mukerji, MD, PhD, Kendrick Shaw, MD, PhD, Sudeshna Das, PhD, Gene Bowman, ND, MPH, Greg Fricchione, MD, Steve Pieper, PhD, Randy Gollub, MD, PhD, Beth Klerman, PhD, MD, Syd Cash, MD, PhD, Seun Akeju, MD, Jonathan Rosand, MD, Rudy Tanzi, PhD
- Boston Children's Hospital: Umakanth Katwa, MD
- Stanford University: Emmanuel Mignot, MD, PhD
- Emory University: Lynn Marie Trotti, MD, Gari Clifford, PhD,
- Kaiser Permanente: Dennis Hwang, MD
- University of Wisconsin-Madison: Aaron Struck, MD
- Yale School of Medicine: Jennifer Kim, MD, PhD)
- University of Illinois at Urbana Champaign: Jimeng Sun, PhD
- Washington University School of Medicine in St. Louis: Fabio Nascimento, MD
- Brigham and Women's Hospital: Jong Woo Lee, MD, PhD
- Duke University: Cynthia Rudin, PhD, Alex Volfovsky, PhD
- University of California San Francisco: Eddy Amorim, MD
- Northwestern Feinberg School of Medicine: Eyal Kimchi, MD, PhD
BDSP support comes from the National Institutes of Health (NIH), including the National Institute of Neurological Disorders and Stroke (NINDS: R01NS102190, R01NS107291, RF1NS120947, R01NS126282), the National Heart, Lung, and Blood Institute (NHLBI: R01HL161253), the National Science Foundation (NSF: grant 2014431), and the MGH McCance Center for Brain Health.
If you use data or software from BDSP in a publication, please acknowledge the author(s). You can find authors' names and publications on the project pages for their contributions. If you are unsure how to cite a specific project, please ask us.
The BDSP is maintained by researchers and engineers at the Clinical Data Animation Center and the McCance Center for Brain Health L. To reach us, email email@example.com.