Resources


Database Credentialed Access

Automated detection of immune effector cell-associated neurotoxicity syndrome (ICANS) via quantitative EEG

Christine Eckhardt, Haoqi Sun, Jin Jing, Daniel Rubin, Eyal Kimchi, Sydney Cash, Matthew J. Frigault, Jong Woo Lee, Jorg Dietrich, M Brandon Westover

Dataset and code for developing and validating the EICANS score, a machine learning–derived EEG metric for automated detection and grading of immune effector cell-associated neurotoxicity syndrome (ICANS) in patients receiving CAR-T cell therapy.

car-t encephalopathy neurotoxicity eeg

Published: Feb. 9, 2026. Version: 1.0

Software Credentialed Access

Epileptiform activity and outcomes in toxic-metabolic encephalopathy

Paul M. Chen, Saskia S. Schuurmans Stekhoven, Hiba Haider, Jin Jing, Wendong Ge, Eric Rosenthal, M. Brandon Westover, Sahar F. Zafar

De-identified data and reproduction code for a retrospective cEEG study of ictal-interictal continuum patterns and outcomes in 121 patients with toxic-metabolic encephalopathy (MGH, 2012-2017).

Published: July 10, 2026. Version: 1.0.0

Database Credentialed Access

Neurophysiologic Encephalopathy Severity Index (NESI) - Data and Code

Arka Roy, Katelyn Surrao, ChenXi Sun, Jin Jing, Tianyu Zhang, Aditya Gupta, Ryan A. Tesh, Imad Akbar, Kaileigh Gallagher, Marjan Sarami, Rajib Kanti Dey, Aysenur Yaramis, Alihan Yaramis, Zeeshan Haider, Utsav Patel, Laraib Jumani, Grace Bayas, Haoqi Sun, Wolfgang Ganglberger, Erika L. Juarez Martinez, Fábio A. Nascimento, Irfan S. Sheikh, Oluwaseun Akeju, Miles Berger, Eyal Y. Kimchi, Sahar F. Zafar, Christine A. Eckhardt, M Brandon Westover

A continuous, EEG-based index of encephalopathy severity (NESI) that maps RASS, GCS, CAM-S, and ICANS onto one physiological axis. Includes 10-minute EEG segments, MORGOTH features, trained models, derived tables, and the full analysis code.

Published: June 14, 2026. Version: 1.0.0

Software Credentialed Access

Forecasting immune effector cell-associated neurotoxicity syndrome after CAR T-cell therapy

Yalda Amidi, Christine Eckhardt, Syed Quadri, Preeti Malik, Marcos Santana Firme, Daniel Jones, Aayushee Jain, Husnain H. Danish, Daniel Rubin, Caron Jacobson, Sydney Cash, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover

MATLAB code and de-identified data to forecast the onset and day-by-day trajectory of ICANS after CAR T-cell therapy (combined hidden Markov model + lasso logistic regression; 199-patient cohort, leave-one-patient-out cross-validation).

Published: July 7, 2026. Version: 1.0.0

Database Open Access

VE-CAM-S: Visual EEG-Based Grading of Delirium Severity and Associations with Clinical Outcomes

Ryan Tesh, Haoqi Sun, Jin Jing, Mike Westmeijer, Anudeepthi Neelagiri, Subapriya Rajan, Parimala Velpula Krishnamurthy, Pooja Sikka, Syed Quadri, Michael Leone, Luis Paixao, Ezhil Panneerselvam, Christine Eckhardt, Aaron F Struck, Peter Kaplan, Oluwaseun Akeju, Daniel Jones, Eyal Kimchi, M Brandon Westover

This dataset supports a published prospective cohort study using machine learning to develop the Visual EEG Confusion Assessment Method Severity (VE-CAM-S) scale for quantifying delirium and coma severity.

Published: Jan. 5, 2024. Version: 1.0

Database Restricted Access

Real-Time Segmentation of Burst Suppression Patterns in Critical Care EEG Monitoring

Mouhsin Shafi, Valdery Moura Junior, Aditya Gupta, Manohar Ghanta, M Brandon Westover

Data and code to automatically detect periods of suppression in critically ill ICU patients.

Published: Dec. 7, 2023. Version: 1.0