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Automated detection of immune effector cell-associated neurotoxicity syndrome (ICANS) via quantitative EEG

Christine Eckhardt, Haoqi Sun, Jin Jing, Daniel Rubin, Eyal Kimchi, Sydney Cash, Matthew J. Frigault, Jong Woo Lee, Jorg Dietrich, M Brandon Westover

Dataset and code for developing and validating the EICANS score, a machine learning–derived EEG metric for automated detection and grading of immune effector cell-associated neurotoxicity syndrome (ICANS) in patients receiving CAR-T cell therapy.

car-t encephalopathy neurotoxicity eeg

Published: Feb. 9, 2026. Version: 1.0

Software Credentialed Access

Forecasting immune effector cell-associated neurotoxicity syndrome after CAR T-cell therapy

Yalda Amidi, Christine Eckhardt, Syed Quadri, Preeti Malik, Marcos Santana Firme, Daniel Jones, Aayushee Jain, Husnain H. Danish, Daniel Rubin, Caron Jacobson, Sydney Cash, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover

MATLAB code and de-identified data to forecast the onset and day-by-day trajectory of ICANS after CAR T-cell therapy (combined hidden Markov model + lasso logistic regression; 199-patient cohort, leave-one-patient-out cross-validation).

Published: July 7, 2026. Version: 1.0.0

Software Credentialed Access

EEG-based grading of immune effector cell-associated neurotoxicity syndrome

Daniel Jones, Christine Eckhardt, Haoqi Sun, Ryan A. Tesh, Preeti Malik, Syed Quadri, Marcos Santana Firme, Meike van Sleuwen, Aayushee Jain, Ziwei Fan, Jin Jing, Wendong Ge, Fábio A. Nascimento, Irfan S. Sheikh, Caron Jacobson, Matthew J. Frigault, Eyal Y. Kimchi, Sydney Cash, Jong Woo Lee, Jorg Dietrich, M. Brandon Westover

An interpretable ordinal EEG-feature score (VE-ICANS) that grades the severity of immune effector cell-associated neurotoxicity syndrome (ICANS) after CAR-T therapy. Code + de-identified data.

Published: July 7, 2026. Version: 1.0.0